SULFATRIM INJECTION Solution is indicated in the treatment of systemic infections caused by or associated with organisms sensitive to the Trimethoprim: Sulfadiazine combination. The spectrum of activity includes both Gram-positive and Gram-negative organisms including: Actinobacilli, Actinomycae, Bordetella spp, Brucella Corynebacteria, Escherichia coli, Haemophilus spp. Klebsiella spp, Pasteurella spp, Pneumococci. Proteus, Salmonella spp. Staphylococci, Streptococci, Vibrio.